Invention Grant
- Patent Title: Colorimetric test for antimalarial artemesin derivatives
- Patent Title (中): 抗疟药青蒿素衍生物的比色试验
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Application No.: US12741434Application Date: 2008-11-05
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Publication No.: US08435794B2Publication Date: 2013-05-07
- Inventor: Michael D. Green
- Applicant: Michael D. Green
- Applicant Address: US DC Washington
- Assignee: The United States of America, as Represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
- Current Assignee: The United States of America, as Represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
- Current Assignee Address: US DC Washington
- Agency: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.
- International Application: PCT/US2008/082466 WO 20081105
- International Announcement: WO2009/061808 WO 20090514
- Main IPC: G01N33/00
- IPC: G01N33/00
Abstract:
A process for testing a composition as containing an artemisinin derivative is provided that includes contacting the composition with a reagent made up of a hydrogen bonding polar organic solvent and an acid having a pK value of less than 3.8 at 25° Celsius and capable of acid catalyzing a decomposition reaction of the artemisinin derivative so as to provide a reaction mixture. The reaction mixture is allowed sufficient time at a reaction temperature for the artemisinin derivative to decompose to yield a colored decomposition product discerned by a normal unaided human eye. A kit for testing a composition for an artemisinin derivative according to the process is provided together with instructions for contacting the solvent and the acid with the composition to decompose the artemisinin derivative to yield the colored decomposition.
Public/Granted literature
- US20100297775A1 COLORIMETRIC TEST FOR ANTIMALARIAL ARTEMESIN DERIVATIVES Public/Granted day:2010-11-25
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