Invention Grant
US08435748B2 Method for monitoring, diagnosing, and screening cancer through measuring the concentration of des-R prothrombin activation peptide fragment F2 (des-R F2) in a serum
有权
通过测定血清中des-R凝血酶原活化肽片段F2（des-R F2）的浓度来监测，诊断和筛选癌症的方法
- Patent Title: Method for monitoring, diagnosing, and screening cancer through measuring the concentration of des-R prothrombin activation peptide fragment F2 (des-R F2) in a serum
- Patent Title (中): 通过测定血清中des-R凝血酶原活化肽片段F2（des-R F2）的浓度来监测，诊断和筛选癌症的方法
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Application No.: US12993198Application Date: 2009-03-13
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Publication No.: US08435748B2Publication Date: 2013-05-07
- Inventor: Chul Woo Kim , Pil Je Park , Yong-Sung Shin , Kil Hyon Lee , Ho Sang Shin , Byoung-Kwon Kim
- Applicant: Chul Woo Kim , Pil Je Park , Yong-Sung Shin , Kil Hyon Lee , Ho Sang Shin , Byoung-Kwon Kim
- Applicant Address: KR Seoul
- Assignee: Bioinfra Inc.
- Current Assignee: Bioinfra Inc.
- Current Assignee Address: KR Seoul
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2008-0023803 20080314
- International Application: PCT/KR2009/001266 WO 20090313
- International Announcement: WO2009/113832 WO 20090917
- Main IPC: G01N33/53
- IPC: G01N33/53
Abstract:
The present invention relates to a method for diagnosis and screening of cancer by measuring the expression of des-R prothrombin activation peptide fragment F2 (des-R F2) in serum, more precisely, des-R-prothrombin activation peptide fragment F2 which is the protein marker down-regulated specifically in liver cancer, breast cancer, and stomach cancer, and a method for diagnosis and screening of liver cancer, breast cancer, and stomach cancer by quantifying the protein marker. The protein marker of the present invention can be effectively used for diagnosis and screening of liver cancer, breast cancer and stomach cancer by comparing the expression of the said protein marker in a normal subject with that of a liver cancer, breast cancer, or stomach cancer patients.
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