Pliable-wall air ducts with suspended frames are disclosed herein. An example air duct system includes an air duct having a pliable sidewall to extend in a longitudinal direction, the pliable sidewall having a total weight and a framework to be disposed within the air duct. The framework includes a shaft extending in the longitudinal direction, a rib to engage an inner surface of the air duct and a plurality of spokes connecting the rib to the shaft. The example air duct system includes one or more hangers comprising an elongate member having an upper section and a lower section. The lower section to extend through a corresponding opening defined by the pliable side wall and to be coupled to the framework. Most of the total weight of the pliable sidewall is to be carried by the framework.