An interference cancellation method include detecting macro terminals which experience interference between a first signal output from a macro base-station and a second signal delivered from a femto terminal that is greater than a reference value; determining the number of channels of the femto base-station by subtracting the number of the detected macro terminals from the number of antennas of the femto base-station; generating a transmission beamforming weight vector using channel information of a signal interfered by the first signal and the second signal and channel information of the first signal; and providing a service, using the transmission beamforming weight vector, to as many femto terminals as the number obtained by subtracting the number of the detected macro terminals, which experience the interference greater than the reference value, from the number of the antennas of the femto base-station.