Circuits and methods for sampling differential input signals having wide input swings including voltages below ground potential, and capable of operating on a single positive supply voltage are disclosed. In an embodiment, the circuit includes a first input switch circuit and a second input switch circuit, a sample and hold circuitry and an operational amplifier. Each of the first and second input switch circuits includes serially connected PMOS switch and NMOS switch for receiving a differential input signal. The sample and hold circuitry includes a first sampling capacitor, a second sampling capacitor and a plurality of switches. The switches are configured to provide the differential input signal to the sampling capacitors for the sampling in a sample phase, and are configured to provide the sampled differential input signal at an output of the operational amplifier in a hold phase.