A fluid injection system may include an injector, a syringe and an anti-rotation connection. The injector may have a drive piston having a plunger engaging end and the syringe may have a body and a plunger within the body. The plunger may have a proximal end with at least one coupling member adapted for engagement by the plunger engaging end. The anti-rotation connection may be formed by complementary anti-rotation elements associated between the proximal end of the plunger and the plunger engaging end of the drive piston to limit rotation of the plunger within the syringe body. The anti-rotation elements may include the at least one coupling member engaged in a radial groove defining at least one axial edge formed on the plunger engaging end to enable limited rotational movement of the plunger relative to the drive piston when the complementary anti-rotation elements are engaged.