Disclosed is a method for extracting a region-of-interest of a user in a multimedia mobile terminal. The method includes: setting a search region in an input picture input to the multimedia mobile terminal on a screen picture-to-screen picture basis, and extracting a group of boundary of a region-of-interest based on a brightness difference between the set search region and an environment around the set search region; determining boundary coordinates of the region-of-interest through learning during a predetermined frame among the extracted group of boundary coordinate candidates; and enlarging the region-of-interest having the determined boundary coordinates, and displaying the enlarged region-of-interest. As a result, a region the user is most interested in or pays more attention to than other regions on a screen is automatically extracted. Accordingly, it is possible for users to view pictures in such an efficient manner as to provide the users with an even better experience and understanding during viewing.