Invention Grant
- Patent Title: Compositions and methods for inhibiting expression of a gene from the JC virus
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Application No.: US13252414Application Date: 2011-10-04
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Publication No.: US08410261B2Publication Date: 2013-04-02
- Inventor: Pamela Tan , Dinah Sah , Birgit Bramlage
- Applicant: Pamela Tan , Dinah Sah , Birgit Bramlage
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Fenwick & West LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C12N15/11 ; C12N5/00 ; A61K9/127
Abstract:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.
Public/Granted literature
- US20120022141A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE JC VIRUS Public/Granted day:2012-01-26
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