Invention Grant
- Patent Title: Fused bicyclic compound
- Patent Title (中): 稠合双环化合物
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Application No.: US13561662Application Date: 2012-07-30
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Publication No.: US08410166B2Publication Date: 2013-04-02
- Inventor: Yoichi Takahashi , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iljima
- Applicant: Yoichi Takahashi , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iljima
- Applicant Address: JP Osaka
- Assignee: Mitsubishi Tanabe Pharma Corporation
- Current Assignee: Mitsubishi Tanabe Pharma Corporation
- Current Assignee Address: JP Osaka
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2007-200264 20070801
- Main IPC: C07D265/00
- IPC: C07D265/00

Abstract:
Fused bicyclic compound having an affinity to mineral corticoid receptor (MR), of formula [I]: wherein ring A is benzene having a substituent R1, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R1, R1 is alkylsulfonylamino, etc., R2 and R3 are (a) the same of different and are hydrogen, alkyl, or optionally substituted aryl, or (b) combined with each other to form an oxo group or (c) combined with each other at its terminal together with the adjacent carbon atom to form cycloalkyl, X is ═N—, ═C(R4)— or —CH(R4)—, R4 is (a) hydrogen, (b) cyano, (c) halogen, (d) alkyl, (e) alkenyl, (f) cycloalkyl, (g) alkanoyl, (h) carbamoyl, or (i) cycloalkenyl, Ar is an optionally substituted aromatic cyclic group and a dotted line means presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, useful e.g. as an antihypertensive agent.
Public/Granted literature
- US20130029979A1 FUSED BICYCLIC COMPOUND Public/Granted day:2013-01-31
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