Invention Grant
US08410116B2 Bis(styryl)pyrimidine or bis(styryl)benzene compounds, pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition for prevention or treatment of diseases featuring amyloids comprising the same as an active ingredient
有权
双（苯乙烯基）嘧啶或双（苯乙烯基）苯化合物，其药学上可接受的盐，其制备方法和用于预防或治疗具有包含其作为活性成分的淀粉样蛋白的疾病的药物组合物
- Patent Title: Bis(styryl)pyrimidine or bis(styryl)benzene compounds, pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition for prevention or treatment of diseases featuring amyloids comprising the same as an active ingredient
- Patent Title (中): 双（苯乙烯基）嘧啶或双（苯乙烯基）苯化合物，其药学上可接受的盐，其制备方法和用于预防或治疗具有包含其作为活性成分的淀粉样蛋白的疾病的药物组合物
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Application No.: US12429552Application Date: 2009-04-24
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Publication No.: US08410116B2Publication Date: 2013-04-02
- Inventor: Kye Jung Shin , Eun Joo Roh , Yun Suk Lee
- Applicant: Kye Jung Shin , Eun Joo Roh , Yun Suk Lee
- Applicant Address: KR Seoul
- Assignee: Korea Institute of Science and Technology
- Current Assignee: Korea Institute of Science and Technology
- Current Assignee Address: KR Seoul
- Agency: Ladas & Parry LLP
- Priority: KR10-2009-0006092 20090123
- Main IPC: C07D239/34
- IPC: C07D239/34 ; A61K31/505
Abstract:
Disclosed are bis(styryl)pyrimidine or bis(styryl)benzene compounds, represented by Chemical Formula 1, pharmaceutically acceptable salts, a method for preparing the same, and a pharmaceutical composition for the prevention and treatment of amyloidosis-associated diseases, comprising the same as an active ingredient. Having the ability to inhibit the deposition of beta amyloid and to reduce the toxicity of beta amyloid, the derivatives can improve learning and memory and can be useful in the prevention and treatment of amyloidosis-associated diseases. (wherein R1, R2, R3 and X are as defined in the specification).
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