Invention Grant
US08410114B2 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial
失效
2-吡嗪酮衍生物用于治疗嗜中性粒细胞弹性蛋白酶活性抑制有益的疾病或病症
- Patent Title: 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial
- Patent Title (中): 2-吡嗪酮衍生物用于治疗嗜中性粒细胞弹性蛋白酶活性抑制有益的疾病或病症
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Application No.: US13344658Application Date: 2012-01-06
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Publication No.: US08410114B2Publication Date: 2013-04-02
- Inventor: Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lonn , Antonios Nikitidis , Asim Ray
- Applicant: Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lonn , Antonios Nikitidis , Asim Ray
- Applicant Address: SE Sodertalje
- Assignee: AstraZeneca AB
- Current Assignee: AstraZeneca AB
- Current Assignee Address: SE Sodertalje
- Agent David Gryte
- Main IPC: A61K31/4965
- IPC: A61K31/4965
Abstract:
The invention provides compounds of formula wherein R1, R3, R4, R5, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
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