Invention Grant
US08410048B2 Method for producing insulin analogs having a dibasic B chain terminus
有权
用于生产具有二元B链末端的胰岛素类似物的方法
- Patent Title: Method for producing insulin analogs having a dibasic B chain terminus
- Patent Title (中): 用于生产具有二元B链末端的胰岛素类似物的方法
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Application No.: US12349854Application Date: 2009-01-07
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Publication No.: US08410048B2Publication Date: 2013-04-02
- Inventor: Paul Habermann , Frank Zocher
- Applicant: Paul Habermann , Frank Zocher
- Applicant Address: DE Frankfurt am Main
- Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee Address: DE Frankfurt am Main
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: DE102006031955 20060711
- Main IPC: A61K38/28
- IPC: A61K38/28 ; A61K38/48 ; C07K14/62 ; C12N9/76
Abstract:
The invention relates to a method for producing a type of insulin by genetically engineering a precursor thereof and converting said precursor to the respective insulin in an enzyme-catalyzed ligation reaction with lysine amide or arginine amide, or by lysine or arginine which is modified by protective groups, and optionally subsequent hydrolysis.
Public/Granted literature
- US20090192073A1 METHOD FOR PRODUCING INSULIN ANALOGS HAVING A DIBASIC B CHAIN TERMINUS Public/Granted day:2009-07-30
Information query
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