Invention Grant
- Patent Title: Sustained drug-releasing stent
- Patent Title (中): 持续放药支架
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Application No.: US12733460Application Date: 2008-09-03
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Publication No.: US08409272B2Publication Date: 2013-04-02
- Inventor: Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
- Applicant: Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
- Applicant Address: JP Okayama JP Shibuya JP Hiroshima JP Kyoto
- Assignee: Japan Stent Technology Co., Ltd.,Tokai University Educational System,Toyo Advanced Technologies Co., Ltd.,Hiroo Iwata
- Current Assignee: Japan Stent Technology Co., Ltd.,Tokai University Educational System,Toyo Advanced Technologies Co., Ltd.,Hiroo Iwata
- Current Assignee Address: JP Okayama JP Shibuya JP Hiroshima JP Kyoto
- Priority: JP2007-228788 20070904
- International Application: PCT/JP2008/002410 WO 20080903
- International Announcement: WO2009/031295 WO 20090312
- Main IPC: A61F2/82
- IPC: A61F2/82

Abstract:
A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.
Public/Granted literature
- US20100198344A1 SUSTAINED DRUG-RELEASING STENT Public/Granted day:2010-08-05
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