In response to receiving pre-processed code, a compiler identifies a code section that is not a candidate for acceleration and a code block that is a candidate for acceleration. The code block specifies an iterated operation having a first operand and a second operand, where each of multiple first operands and each of multiple second operands for the iterated operation has a defined addressing relationship. In response to the identifying, the compiler generates post-processed code containing lower level instruction(s) corresponding to the identified code section and creates and outputs an operand data structure separate from the post-processed code. The operand data structure specifies the defined addressing relationship for the multiple first operands and for the multiple second operands. The compiler places a block computation command in the post-processed code that invokes processing of the operand data structure to compute operand addresses.