In some embodiments, a portable multifunction device with a touch screen display concurrently displays on the touch screen display a plurality of predefined regions, the predefined regions including: a source region, a command region, and a destination region. In response to detecting a first command association input by a user on the touch screen display, the device associates a first icon from the source region with a first directory management command icon in the command region. In response to detecting a first command performance input that includes selecting a first folder icon in the destination region, the device performs a directory management operation on a folder or file that corresponds to the first icon. The directory management operation is in accordance with the first directory management command icon and the selected first folder in the destination region.