A medicine management apparatus includes: a medicine storage which stores a plurality of medicines used at a site of medical care; a storage and retrieval detector which, when a medicine handling personnel manipulates the apparatus to store or retrieve an accommodated medicine to be accommodated in the apparatus, physically detects the target accommodated medicine for which the apparatus is manipulated, differentiating it from the other accommodated medicines; and a counter which counts each type of the plurality of accommodated medicines. An injection prescription receiver receives injection prescription data from an external prescription analyzer. A retrieval determining unit determines whether the accommodated medicine detected as being retrieved is the accommodated medicine directed by the injection prescription data to be retrieved. A retrieval completion notification unit transmits a retrieval completion signal to the prescription analyzer, prompted by the completion of the retrieval of the accommodated medicine directed by the prescription data to be retrieved.