Invention Grant
US08404458B2 Histone modifications as binary switches controlling gene expression
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组蛋白修饰作为控制基因表达的二进制开关
- Patent Title: Histone modifications as binary switches controlling gene expression
- Patent Title (中): 组蛋白修饰作为控制基因表达的二进制开关
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Application No.: US10571648Application Date: 2004-09-15
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Publication No.: US08404458B2Publication Date: 2013-03-26
- Inventor: C. David Allis , Wolfgang Fischle , Holger Dormann
- Applicant: C. David Allis , Wolfgang Fischle , Holger Dormann
- Applicant Address: US NY New York
- Assignee: The Rockefeller University
- Current Assignee: The Rockefeller University
- Current Assignee Address: US NY New York
- Agency: LeClairRyan, a Professional Corporation
- International Application: PCT/US2004/030161 WO 20040915
- International Announcement: WO2005/028620 WO 20050331
- Main IPC: G01N33/573
- IPC: G01N33/573 ; C07K14/435 ; C12N9/12
Abstract:
The present invention relates to a method of modulating a chromatin binding protein or complex which binds to a functional group on an amino acid of a histone. This method involves phosphorylating or dephosphorylating a serine or threonine on the histone proximate to the amino acid under conditions effective to modulate the chromatin binding protein or complex. This method is particularly useful in treating or preventing cancer in a subject. In addition, the histone comprising a serine or threonine proximate to an amino acid capable of binding to a functional group can be used to screen for compounds which prevent or treat cancer. Also disclosed is an antibody or binding portion thereof raised against a binary switch on a histone comprising a phosphorylated serine or threonine proximate to an amino acid bound to a functional group and its use in detecting a condition mediated by that switch.
Public/Granted literature
- US20070274912A1 Histone Modifications as Binary Switches Controlling Gene Expression Public/Granted day:2007-11-29
Information query
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