Active optical cable assemblies, and systems, methods, and adapter modules and integrated circuits for facilitating communication between a host and a client device over a fiber optic cable are disclosed. In one embodiment, an active optical cable assembly includes a fiber optic cable having at least one optical fiber, a host active circuit, a client active circuit, a host connector, and a client connector. Upon a connection between the host active circuit and a host device, the client termination switch closes to couple the client termination impedance to the ground reference potential. Upon a connection between the client active circuit and a client device, the host termination switch closes to the couple the host termination impedance to the ground reference potential. In another embodiment, a method includes enabling a host termination impedance upon a connection of an active optical cable to a client device.