A solid-state image pickup device includes a pixel array, a gain adjusting unit that adjusts a gain of a pixel signal, an A/D conversion unit that performs A/D conversion on an image pickup signal, a plurality of fixed pattern noise detection units that detect a fixed pattern noise from a digital image pickup signal, a selecting unit that selects one output from outputs of the plurality of fixed pattern noise detection units, a fixed pattern noise correction unit that corrects the fixed pattern noise included in the digital image pickup signal, and a control unit that controls the gain adjusting unit setting a plurality of gain values, the control unit controlling the plurality of fixed pattern noise detection units detecting the plurality of fixed pattern noise based on the plurality of gain values and storing a plurality of correction values.