Invention Grant
- Patent Title: Compound having affinity for amyloid
- Patent Title (中): 对淀粉样蛋白具有亲和力的化合物
-
Application No.: US12739624Application Date: 2008-10-24
-
Publication No.: US08399672B2Publication Date: 2013-03-19
- Inventor: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- Applicant: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- Applicant Address: JP Tokyo
- Assignee: Nihon Medi-Physics Co., Ltd.
- Current Assignee: Nihon Medi-Physics Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fitch, Even, Tabin & Flannery, LLP
- Priority: JP2007-278504 20071026
- International Application: PCT/JP2008/069336 WO 20081024
- International Announcement: WO2009/054497 WO 20090430
- Main IPC: C07D491/02
- IPC: C07D491/02 ; C07D498/02

Abstract:
A compound effective as a probe targeting amyloid for image diagnosis and a reagent comprising the compound for detecting amyloid deposited on a biological tissue are provided. Provided are a compound represented by the following formula (1): wherein R1, R2 and R3 independently represent a group selected from the group consisting of a hydrogen, hydroxyl group, alkyl substituent with 1 to 4 carbon atoms, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and halogen substituent, excluding the case where two or more of the substituents R1, R2 and R3 are hydrogen, R4 is a group selected from the group consisting of a hydrogen, hydroxyl group, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and halogen substituent, and m is an integer of 1 to 4, provided that at least one of R1, R2, R3 and R4 represents a radioactive halogen substituent, and a reagent comprising the same.
Public/Granted literature
- US20100292479A1 NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID Public/Granted day:2010-11-18
Information query