Invention Grant
- Patent Title: Antidiabetic tricyclic compounds
- Patent Title (中): 抗糖尿病三环化合物
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Application No.: US12738857Application Date: 2008-10-27
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Publication No.: US08399507B2Publication Date: 2013-03-19
- Inventor: Gui-Bai Liang , Xibin Liao , Weiguo Liu , Paul E. Finke , Dooseop Kim , Lihu Yang , Songnian Lin
- Applicant: Gui-Bai Liang , Xibin Liao , Weiguo Liu , Paul E. Finke , Dooseop Kim , Lihu Yang , Songnian Lin
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Anna L. Cocuzzo; Kenrick L. Vidale; John C. Todaro
- International Application: PCT/US2008/012181 WO 20081027
- International Announcement: WO2009/058237 WO 20090507
- Main IPC: A61K31/38
- IPC: A61K31/38 ; A61K31/34 ; C07D305/00 ; C07C62/00

Abstract:
Tricyclic compounds containing a cyclopropanecarboxylic acid fused to a bicyclic ring, including pharmaceutically acceptable salts, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Public/Granted literature
- US20100216694A1 ANTIDIABETIC TRICYCLIC COMPOUNDS Public/Granted day:2010-08-26
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