Invention Grant
US08399471B2 Aryl-or heteroaryl-substituted pyrido[2,3-d] pyrimidines and pharmaceutical compositions of the same
有权
芳基或杂芳基取代的吡啶并[2,3-d]嘧啶及其药物组合物
![Aryl-or heteroaryl-substituted pyrido[2,3-d] pyrimidines and pharmaceutical compositions of the same](/docs/US/2013-03-19/US08399471B2/abs.jpg.600x600.jpg)
- Patent Title: Aryl-or heteroaryl-substituted pyrido[2,3-d] pyrimidines and pharmaceutical compositions of the same
- Patent Title (中): 芳基或杂芳基取代的吡啶并[2,3-d]嘧啶及其药物组合物
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Application No.: US12303369Application Date: 2007-05-25
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Publication No.: US08399471B2Publication Date: 2013-03-19
- Inventor: Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr
- Applicant: Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr
- Applicant Address: DE Monheim
- Assignee: Bayer Intellectual Property GmbH
- Current Assignee: Bayer Intellectual Property GmbH
- Current Assignee Address: DE Monheim
- Agent Karen B. King
- Priority: DE102006026583 20060607
- International Application: PCT/EP2007/004690 WO 20070525
- International Announcement: WO2007/140894 WO 20071213
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K32/519 ; A61P9/00
![Aryl-or heteroaryl-substituted pyrido[2,3-d] pyrimidines and pharmaceutical compositions of the same](/abs-image/US/2013/03/19/US08399471B2/abs.jpg.150x150.jpg)
Abstract:
The present application relates to novel aryl- or heteroaryl-substitued pyrido[2,3-d] pyrimidines of formula (I), pharmaceuitical compositions of the same, and a process for their preparation. Formula(I) is: wherein Ar is an aryl or heteroaryl substituent, and R1, R2, R3, Ar, D, and E are as defined in the specification. Compounds and compositions of the present invention can be used in the treatment and/or prophylaxis of various disorders in humans and animals, including aldosteronism, high blood pressure, chronic heart failure, the sequelae of a myocardial infarction, cirrhosis of the liver, renal failure, and stroke.
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