Invention Grant
US08399448B2 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis
有权
6-氨基 - 嘧啶-4-甲酰胺衍生物和与鞘氨醇1-磷酸（S1P）受体结合以治疗多发性硬化症的相关化合物
- Patent Title: 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis
- Patent Title (中): 6-氨基 - 嘧啶-4-甲酰胺衍生物和与鞘氨醇1-磷酸（S1P）受体结合以治疗多发性硬化症的相关化合物
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Application No.: US12671996Application Date: 2008-07-29
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Publication No.: US08399448B2Publication Date: 2013-03-19
- Inventor: Agnes Bombrun , Matthias Schwarz , Stefano Crosignani , David Covini , Delphine Marin
- Applicant: Agnes Bombrun , Matthias Schwarz , Stefano Crosignani , David Covini , Delphine Marin
- Applicant Address: CH Coinsins, Vaud
- Assignee: Merck Serono SA
- Current Assignee: Merck Serono SA
- Current Assignee Address: CH Coinsins, Vaud
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: EP07113992 20070808
- International Application: PCT/EP2008/059933 WO 20080729
- International Announcement: WO2009/019167 WO 20090212
- Main IPC: A61K31/33
- IPC: A61K31/33 ; A61K31/497 ; A61K31/535 ; C07D239/24 ; C07D401/12 ; C07D403/12 ; C07D413/12
Abstract:
The invention relates to compounds of formula (I): wherein X, W, Q, R, R1 and R2 have the meanings given in claim 1. The compounds are useful, for example, in the treatment of autoimmune disorders, such as multiple sclerosis.
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