Invention Grant
- Patent Title: Immunogenic formulation
- Patent Title (中): 免疫原性制剂
-
Application No.: US12679091Application Date: 2008-09-17
-
Publication No.: US08398993B2Publication Date: 2013-03-19
- Inventor: Alexis Mikes Kalergis Parra , Pablo Alberto Gonzalez Munoz , Susan Marcela Bueno Ramirez
- Applicant: Alexis Mikes Kalergis Parra , Pablo Alberto Gonzalez Munoz , Susan Marcela Bueno Ramirez
- Applicant Address: CL Santiago
- Assignee: Pontificia Universidad Catolica de Chile
- Current Assignee: Pontificia Universidad Catolica de Chile
- Current Assignee Address: CL Santiago
- Agency: Venable LLP
- Agent Nancy J. Axelrod; Michael A. Gollin
- Priority: CL2710-2007 20070920
- International Application: PCT/US2008/076682 WO 20080917
- International Announcement: WO2009/039178 WO 20090326
- Main IPC: A61K39/155
- IPC: A61K39/155 ; A61K39/04 ; A61K39/02

Abstract:
The present invention describes an immunogenic formulation to be used in mammals against the respiratory syncytial virus (RSV), consisting in the Calmette-Guérin bacillus (BCG) strain or other attenuated Mycobacterium strain that expresses heterologously at least one protein or immunogenic fragment of the RSV subtype A or RSV subtype B strains, originated from proteins NS1, NS2, N, P, M, SH, M2 (ORF1), M2 (ORF2), L, F or G. The genetic material that encodes for these proteins or immunogenic fragments is inserted into the BCG genome or extrachromosomally in one or several copies, which expression is regulated by endogenous or exogenous BCG promoters, either constitutive or inducible. The viral proteins or immunogenic fragments can be expressed by BCG as cytoplasmic-soluble, extracellularly-secreted or cell membrane-bound proteins. The preparation can further contain combinations of previously described formulations. The formulation can be stabilized by freeze-drying (conservation range from 4° C. and 25° C.) or through low temperatures (−80° C.) in a buffered saline solution to be conserved prior to its use.
Public/Granted literature
- US20110200634A1 IMMUNOGENIC FORMULATION Public/Granted day:2011-08-18
Information query