The present invention is a cargo restraint system for protecting a barrel-contained cargo in a cargo vehicle space during transportation. In one example, the cargo vehicle may contain two sets of stacked barrels with each set having three vertical levels of barrels. In a first embodiment of the invention, the cargo restraint system includes at least one crush cushion placed at either a front end or a back end of the barrel-contained cargo. The crush cushion provides at least five contact points against each barrel and the contact points are arranged along three levels of crush zones. An end-wall system is placed adjacent to the crush cushion. At least one angle member with a plurality of strap separation slots is coupled to the end-wall system. Each strap is threaded through the strap separation slots and is anchored to the cargo vehicle to securely hold the barrel-contained cargo to the crush cushion and the end wall system.