Mandrel coating assemblies are provided, as well as methods for coating endoluminal medical devices with a therapeutic agent using the mandrel coating assembly. The endoluminal medical device may be a stent, valve or other medical device, and may include a plurality of interconnected members defining a lumen and plurality of openings positioned along the abluminal surface in communication with the lumen. The mandrel coating assembly may be configured to minimize the coating penetration on the luminal surface of the medical device and/or incidence of webbing or agglomerations of the coating within the openings between the struts.