Example methods, apparatus, and articles of manufacture to share memory spaces for access by hardware and software in a virtual machine environment are disclosed. A disclosed example method involves enabling a sharing of a memory page of a source domain executing on a first virtual machine with a destination domain executing on a second virtual machine. The example method also involves mapping the memory page to an address space of the destination domain and adding an address translation entry for the memory page in a table. In addition, the example method involves sharing the memory page with a hardware device for direct memory access of the memory page by the hardware device.