A system for monitoring chain of custody of contents of a container includes a lock mechanism configured to lock at least one door of the container in a closed position, a housing enclosing at least a portion of the lock mechanism, and a lock circuit at least partially enclosed within the housing. The lock circuit includes a memory, a lock controller, a wireless module configured to receive information from at least one sensor associated with the container, the information regarding at least one property of the contents of the container, wherein the wireless module is configured to store the information in memory, wherein at least one of the wireless module or the sensor is powered wirelessly, and a lock controller configured to receive commands related to operation of the lock mechanism, to monitor the stored information to identify a change of state of the at least one sensor, and to generate chain of custody data to be transmitted to a remote location via the wireless module. The chain of custody data includes at least two of sensor data, an authentication code associated with the sensor, and/or an authentication code associated with the lock mechanism.