Invention Grant
- Patent Title: Use of specific cyklolignans
- Patent Title (中): 使用特定的cyklolignans
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Application No.: US12508218Application Date: 2009-07-23
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Publication No.: US08389747B2Publication Date: 2013-03-05
- Inventor: Olle Larsson , Magnus Axelson
- Applicant: Olle Larsson , Magnus Axelson
- Applicant Address: SE Stockholm
- Assignee: Axelar AB
- Current Assignee: Axelar AB
- Current Assignee Address: SE Stockholm
- Agency: White & Case LLP
- Priority: SE0102168 20010619
- Main IPC: C07D307/77
- IPC: C07D307/77 ; C07D317/70
Abstract:
The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9′ have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1R dependent diseases, such as cancer, psoriasis, artherosclerosis and acromegaly. A preferred compound is picropodophyllin.
Public/Granted literature
- US20090326248A1 USE OF SPECIFIC CYKLOLIGNANS Public/Granted day:2009-12-31
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