Invention Grant
- Patent Title: Process for the preparation of (R,S)-nicotine
- Patent Title (中): 制备（R，S） - 烟碱的方法
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Application No.: US13647039Application Date: 2012-10-08
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Publication No.: US08389733B2Publication Date: 2013-03-05
- Inventor: Murali Krishna Prasad Divi , Gundu Rao Padakandla , Mysore Aswatha Narayana Rao , Hari Babu Katta
- Applicant: Murali Krishna Prasad Divi , Gundu Rao Padakandla , Mysore Aswatha Narayana Rao , Hari Babu Katta
- Applicant Address: IN
- Assignee: Divi's Laboratories, Ltd.
- Current Assignee: Divi's Laboratories, Ltd.
- Current Assignee Address: IN
- Agency: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
- Priority: IN407/CHE/2011 20110214
- Main IPC: C07D401/04
- IPC: C07D401/04
Abstract:
A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl) pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpynolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
Public/Granted literature
- US20130030187A1 PROCESS FOR THE PREPARATION OF (R,S)-NICOTINE Public/Granted day:2013-01-31
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