Invention Grant
- Patent Title: Process for the synthesis of quetiapine
- Patent Title (中): 喹硫平的合成方法
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Application No.: US13001713Application Date: 2009-01-30
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Publication No.: US08389716B2Publication Date: 2013-03-05
- Inventor: Siro Serafini , Filippo Tomasi , Marco Galvagni
- Applicant: Siro Serafini , Filippo Tomasi , Marco Galvagni
- Applicant Address: IT Alte di Montecchio Maggiore
- Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
- Current Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
- Current Assignee Address: IT Alte di Montecchio Maggiore
- Agency: Dickstein Shapiro LLP
- International Application: PCT/EP2009/000610 WO 20090130
- International Announcement: WO2010/085976 WO 20100805
- Main IPC: C07D281/14
- IPC: C07D281/14
Abstract:
The present invention relates to a process for the synthesis of quetiapine. In particular, a process is provided for the synthesis of quetiapine of formula (A) comprising reacting dibenzo[b,f][1,4]thiazepin-11(10H)-one, intermediate (I) with phosphorous oxychloride to give 11-chlorodibenzo[b,f][1,4]thiazepine, intermediate (II) wherein the said reaction of intermediate (I) to intermediate (II) is performed in an organic solvent in the presence of a mixture of an organic base together with an inorganic base.
Public/Granted literature
- US20110118460A1 PROCESS FOR THE SYNTHESIS OF QUETIAPINE Public/Granted day:2011-05-19
Information query
