Invention Grant
US08389694B2 Biologically active antibodies recognizing a cell surface molecule selectively expressed on living mouse natural type one (I) interferon producing cells
有权
生物活性抗体识别细胞表面分子选择性表达在活的小鼠天然型一（I）干扰素产生细胞
- Patent Title: Biologically active antibodies recognizing a cell surface molecule selectively expressed on living mouse natural type one (I) interferon producing cells
- Patent Title (中): 生物活性抗体识别细胞表面分子选择性表达在活的小鼠天然型一（I）干扰素产生细胞
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Application No.: US11570118Application Date: 2004-11-23
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Publication No.: US08389694B2Publication Date: 2013-03-05
- Inventor: Amanda L. Blasius , Marco Colonna , Marina Cella
- Applicant: Amanda L. Blasius , Marco Colonna , Marina Cella
- Agency: Armstrong Teasdale LLP
- International Application: PCT/US2004/039492 WO 20041123
- International Announcement: WO2005/052126 WO 20050609
- Main IPC: C12P21/08
- IPC: C12P21/08 ; C07K16/00 ; A61K39/00
Abstract:
An isolated and characterized monoclonal antibody (“440c”) prepared by immunizing Wistar/CRL rats subcutaneously with purified rat bone marrow IPC, fusing popliteal lymph nodes of the rats with SP2/0 myeloma spleen cells and differentially selecting for hybridome supernatants that successfully stain bone marrow derived IPC and fractions thereof using CD11c+ spleen cells and, differentially selecting for hybridoma supernatants from the CD11c+ spleen cells that successfully stain only CD 11 c+/Ly6c+/CD 11 b−/B220+ splenocytes to provide the monoclonal antibody.
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