Invention Grant
US08389533B2 Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
有权
双 - 二取代和螺环氨基吡啶/嘧啶作为细胞周期抑制剂
- Patent Title: Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
- Patent Title (中): 双 - 二取代和螺环氨基吡啶/嘧啶作为细胞周期抑制剂
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Application No.: US12936725Application Date: 2009-04-06
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Publication No.: US08389533B2Publication Date: 2013-03-05
- Inventor: Richard V. Connors , Kang Dai , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. McGee , Rajiv Sharma , Xiaodong Wang
- Applicant: Richard V. Connors , Kang Dai , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. McGee , Rajiv Sharma , Xiaodong Wang
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Bernard P. Friedrichsen
- International Application: PCT/US2009/039678 WO 20090406
- International Announcement: WO2009/126584 WO 20091015
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/505 ; C07D237/00 ; C07D239/00 ; C07D241/00
Abstract:
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.
Public/Granted literature
- US20110097305A1 Gem-Disubstituted and Spirocyclic Amino Pyridines/Pyrimidines as Cell Cycle Inhibitors Public/Granted day:2011-04-28
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