Invention Grant
US08389532B2 7-[2-[4-(6-fluoro-3-methyl-1,2-benzisoxazol-5-yl)-1-piperazinyl]ethyl]-2-(1-propynyl)-7H-pyrazolo-[4,3-E]-[1,2,4]-triazolo-[1,5-C]-pyrimidin-5-amine
有权
7- [2- [4-（6-氟-3-甲基-1,2-苯并异恶唑-5-基）-1-哌嗪基]乙基] -2-（1-丙炔基）-7H-吡唑并[4， 3-E] - [1,2,4] - 三唑并 - [1,5-C] - 嘧啶-5-胺
![7-[2-[4-(6-fluoro-3-methyl-1,2-benzisoxazol-5-yl)-1-piperazinyl]ethyl]-2-(1-propynyl)-7H-pyrazolo-[4,3-E]-[1,2,4]-triazolo-[1,5-C]-pyrimidin-5-amine](/docs/US/2013-03-05/US08389532B2/abs.jpg.600x600.jpg)
- Patent Title: 7-[2-[4-(6-fluoro-3-methyl-1,2-benzisoxazol-5-yl)-1-piperazinyl]ethyl]-2-(1-propynyl)-7H-pyrazolo-[4,3-E]-[1,2,4]-triazolo-[1,5-C]-pyrimidin-5-amine
- Patent Title (中): 7- [2- [4-（6-氟-3-甲基-1,2-苯并异恶唑-5-基）-1-哌嗪基]乙基] -2-（1-丙炔基）-7H-吡唑并[4， 3-E] - [1,2,4] - 三唑并 - [1,5-C] - 嘧啶-5-胺
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Application No.: US12498013Application Date: 2009-07-06
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Publication No.: US08389532B2Publication Date: 2013-03-05
- Inventor: Craig D. Boyle , Samuel Chackalamannil , Unmesh Shah , Jean E. Lachowicz
- Applicant: Craig D. Boyle , Samuel Chackalamannil , Unmesh Shah , Jean E. Lachowicz
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent H. Eric Fischer; Gerard M. Devlin
- Main IPC: A61K31/505
- IPC: A61K31/505 ; C07D239/00 ; C07D471/00 ; C07D487/00 ; C07D491/00
![7-[2-[4-(6-fluoro-3-methyl-1,2-benzisoxazol-5-yl)-1-piperazinyl]ethyl]-2-(1-propynyl)-7H-pyrazolo-[4,3-E]-[1,2,4]-triazolo-[1,5-C]-pyrimidin-5-amine](/abs-image/US/2013/03/05/US08389532B2/abs.jpg.150x150.jpg)
Abstract:
The compound having the structural formula I or a pharmaceutically acceptable salt thereof, is disclosed, as well as its use in the treatment of central nervous system diseases, in particular Parkinson's disease, Extra Pyramidal Syndrome, restless legs syndrome and attention deficit hyperactivity disorder, pharmaceutical compositions comprising it, and combinations with other agents.
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