Invention Grant
US08389517B2 Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
有权
葡萄糖神经酰胺合酶抑制治疗塌陷性肾小球病和其他肾小球疾病
- Patent Title: Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
- Patent Title (中): 葡萄糖神经酰胺合酶抑制治疗塌陷性肾小球病和其他肾小球疾病
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Application No.: US13055036Application Date: 2009-07-27
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Publication No.: US08389517B2Publication Date: 2013-03-05
- Inventor: Oxana Ibraghimov-Beskrovnaya , Thomas A. Natoli
- Applicant: Oxana Ibraghimov-Beskrovnaya , Thomas A. Natoli
- Applicant Address: US MA Cambridge
- Assignee: Genzyme Corporation
- Current Assignee: Genzyme Corporation
- Current Assignee Address: US MA Cambridge
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- International Application: PCT/US2009/051864 WO 20090727
- International Announcement: WO2010/014554 WO 20100204
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/4025 ; A61K31/427 ; A61K31/453
Abstract:
A method of treating a glomerular disease selected from the group consisting of mesangial proliferative glomerulonephritis, collapsing glomerulopathy, proliferative lupus nephritis, crescentic glomerulonephritis and membranous nephropathy in a subject comprises administering to the subject an effective amount of a glucosylceramide synthase inhibitor.
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