Invention Grant
US08389513B2 2-amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides
失效
2-氨基-5,5-二氟-5,6-二氢-4H- [1,3]恶嗪-4-基） - 苯基] - 酰胺
![2-amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides](/docs/US/2013-03-05/US08389513B2/abs.jpg.600x600.jpg)
- Patent Title: 2-amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides
- Patent Title (中): 2-氨基-5,5-二氟-5,6-二氢-4H- [1,3]恶嗪-4-基） - 苯基] - 酰胺
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Application No.: US12959412Application Date: 2010-12-03
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Publication No.: US08389513B2Publication Date: 2013-03-05
- Inventor: David Banner , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Emmanuel Pinard , Eoin Power , Mark Rogers-Evans , Thomas Woltering , Wolfgang Wostl
- Applicant: David Banner , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Emmanuel Pinard , Eoin Power , Mark Rogers-Evans , Thomas Woltering , Wolfgang Wostl
- Applicant Address: US NJ Nutley IT Siena
- Assignee: Hoffmann-La Roche Inc.,Siena Biotech S.p.A.
- Current Assignee: Hoffmann-La Roche Inc.,Siena Biotech S.p.A.
- Current Assignee Address: US NJ Nutley IT Siena
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP09178983 20091211
- Main IPC: C07D265/04
- IPC: C07D265/04 ; A61K31/33
![2-amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides](/abs-image/US/2013/03/05/US08389513B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to 2-Amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
Public/Granted literature
- US20110144097A1 2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-PHENYL]-AMIDES Public/Granted day:2011-06-16
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