Invention Grant
- Patent Title: Substituted pyrazole compounds
- Patent Title (中): 取代的吡唑化合物
-
Application No.: US13145728Application Date: 2010-01-22
-
Publication No.: US08389509B2Publication Date: 2013-03-05
- Inventor: Alaric J. Dyckman , William J. Pitts , Scott Hunter Watterson
- Applicant: Alaric J. Dyckman , William J. Pitts , Scott Hunter Watterson
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- International Application: PCT/US2010/021696 WO 20100122
- International Announcement: WO2010/085584 WO 20100729
- Main IPC: A61K31/4155
- IPC: A61K31/4155 ; A61K31/397 ; A61K31/4245 ; C07D231/10 ; C07D271/06 ; C07D205/04

Abstract:
Disclosed are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: n is zero or an integer selected from 1 through 4; R1 is cycloalkyl, aryl, heteroaryl, or heterocyclyl, each optionally substituted with one to five substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, benzyl, —OR4, and/or halogen; and R2, R3, R4, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
Public/Granted literature
- US20110275610A1 SUBSTITUTED PYRAZOLE COMPOUNDS Public/Granted day:2011-11-10
Information query
IPC分类: