Invention Grant
US08389507B2 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands
失效
2-氮杂环丁烷甲烷胺和2-吡咯烷甲烷胺作为TAAR-配体
- Patent Title: 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands
- Patent Title (中): 2-氮杂环丁烷甲烷胺和2-吡咯烷甲烷胺作为TAAR-配体
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Application No.: US12176456Application Date: 2008-07-21
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Publication No.: US08389507B2Publication Date: 2013-03-05
- Inventor: Guido Galley , Annick Goergler , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
- Applicant: Guido Galley , Annick Goergler , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP07113329 20070727
- Main IPC: A01N43/00
- IPC: A01N43/00 ; A61K31/397

Abstract:
The present invention relates to compounds of formula I wherein R1, R2, R3, Ar, n and o are as defined herein and to their pharmaceutically acceptable active salts. Compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1 and are useful for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
Public/Granted literature
- US20090029962A1 2-AZETIDINEMETHANEAMINES AND 2-PYRROLIDINEMETHANEAMINES AS TAAR-LIGANDS Public/Granted day:2009-01-29
Information query
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