Invention Grant
US08389483B2 Intrauterine fetal growth restriction—the treatment modalities for clinical research, and the biochemical rationale 失效
子宫内胎儿生长限制 - 临床研究的治疗方式和生化理论

  • Patent Title: Intrauterine fetal growth restriction—the treatment modalities for clinical research, and the biochemical rationale
  • Patent Title (中): 子宫内胎儿生长限制 - 临床研究的治疗方式和生化理论
  • Application No.: US10460170
    Application Date: 2003-06-13
  • Publication No.: US08389483B2
    Publication Date: 2013-03-05
  • Inventor: Sumathi Paturu
  • Applicant: Sumathi Paturu
  • Main IPC: A61K31/7004
  • IPC: A61K31/7004 C07H3/02
Intrauterine fetal growth restriction—the treatment modalities for clinical research, and the biochemical rationale
Abstract:
Intrauterine Fetal Growth Restriction (IUGR) is a very important clinical problem for which no satisfactory treatment is available so far. The current invention of intravenous (IV) hypertonic glucose supplementation to the mother to improve the glucose transfer to the fetus at the intervillous space by improved facilitated diffusion can be a safe and easy way of treating this problem, as the improved fetal blood glucose can lead to fetal lipogenesis that can conserve the fetal O2 (oxygen) utilization and also relieve the associated metabolic derangements of fetal hypoxia, hypercapnia, and acidosis, apart from replenishing the oxidized coenzymes needed for the carbohydrate metabolism. The use of trans-amniotic fetal feeding studied by animal experiments can be difficult in humans, because of the danger of infection, which can be overcome by the use of implantable ports with a sterile patch technique.
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