Invention Grant
- Patent Title: Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
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Application No.: US12593751Application Date: 2008-03-31
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Publication No.: US08389282B2Publication Date: 2013-03-05
- Inventor: Michel Sadelain , Matthias Stephan
- Applicant: Michel Sadelain , Matthias Stephan
- Applicant Address: US NY New York
- Assignee: Memorial Sloan-Kettering Cancer Center
- Current Assignee: Memorial Sloan-Kettering Cancer Center
- Current Assignee Address: US NY New York
- Agency: Edwards Wildman Palmer LLP
- Agent Peter C. Lauro, Esq.; Melissa Hunter-Ensor, Esq.
- International Application: PCT/US2008/004251 WO 20080331
- International Announcement: WO2008/121420 WO 20081009
- Main IPC: C12N5/16
- IPC: C12N5/16
Abstract:
The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
Public/Granted literature
- US08252592B2 Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes Public/Granted day:2012-08-28
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