Invention Grant
- Patent Title: Production of secreted proteins by filamentous fungi
- Patent Title (中): 丝状真菌生产分泌蛋白
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Application No.: US12444760Application Date: 2007-10-31
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Publication No.: US08389269B2Publication Date: 2013-03-05
- Inventor: Cornelis Maria Jacobus Sagt , Cornelis Theodorus Verrips , Walraven Henry Muller , Noël Nicolaas Maria Elisabeth Van Peij
- Applicant: Cornelis Maria Jacobus Sagt , Cornelis Theodorus Verrips , Walraven Henry Muller , Noël Nicolaas Maria Elisabeth Van Peij
- Applicant Address: NL Heerlen
- Assignee: DSM IP Assets B.V.
- Current Assignee: DSM IP Assets B.V.
- Current Assignee Address: NL Heerlen
- Agency: Baker Donelson Bearman Caldwell & Berkowitz, PC
- Priority: EP06123392 20061102
- International Application: PCT/EP2007/061765 WO 20071031
- International Announcement: WO2008/053018 WO 20080508
- Main IPC: C12N1/00
- IPC: C12N1/00
Abstract:
The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype.
Public/Granted literature
- US20100093030A1 PRODUCTION OF SECRETED PROTEINS BY FILAMENTOUS FUNGI Public/Granted day:2010-04-15
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