Invention Grant
US08389251B2 Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis
有权
使用具有降低甲硫氨酸生物合成负调节子的表达活性的微生物生产甲硫氨酸的方法
- Patent Title: Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis
- Patent Title (中): 使用具有降低甲硫氨酸生物合成负调节子的表达活性的微生物生产甲硫氨酸的方法
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Application No.: US13018119Application Date: 2011-01-31
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Publication No.: US08389251B2Publication Date: 2013-03-05
- Inventor: Markus Pompejus , Burkhard Kröger , Hartwig Schröder , Oskar Zelder , Gregor Haberhauer , Stefan Haefner , Corrinna Klopprogge
- Applicant: Markus Pompejus , Burkhard Kröger , Hartwig Schröder , Oskar Zelder , Gregor Haberhauer , Stefan Haefner , Corrinna Klopprogge
- Applicant Address: DE Essen
- Assignee: Evonik Degussa GmbH
- Current Assignee: Evonik Degussa GmbH
- Current Assignee Address: DE Essen
- Agency: Novak Druce Connolly Bove + Quigg LLP
- Priority: DE19930476 19990701; DE19931419 19990708; DE19931420 19990708; DE19932122 19990709; DE19932128 19990709; DE19932134 19990709; DE19932206 19990709; DE19932207 19990709; DE19933003 19990714; DE19941390 19990831; DE19942088 19990903; DE19942124 19990903
- Main IPC: C12P13/12
- IPC: C12P13/12 ; C12N15/74

Abstract:
Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.
Public/Granted literature
- US20110229937A1 CORYNEBACTERIUM GLUTAMICUM GENES ENCODING REGULATORY PROTEINS INVOLVED IN THE PRODUCTION OF METHIONINE Public/Granted day:2011-09-22
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