Invention Grant
- Patent Title: Assays, method and compositions that exploit a mycobacterial iron acquistion pathway in cells
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Application No.: US11990718Application Date: 2006-08-23
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Publication No.: US08389231B2Publication Date: 2013-03-05
- Inventor: John T. Groves
- Applicant: John T. Groves
- Applicant Address: US NJ Princeton
- Assignee: The Trustees of Princeton University
- Current Assignee: The Trustees of Princeton University
- Current Assignee Address: US NJ Princeton
- Agency: Potter Anderson & Corroon, LLP
- International Application: PCT/US2006/032933 WO 20060823
- International Announcement: WO2007/024960 WO 20070301
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; C12Q1/02
Abstract:
Assays for the identification of antibacterial agents that inhibit mycobacterial growth by interfering with the iron acquisition pathway in host cells are disclosed. Also disclosed are methods of inhibiting mycobacterial growth by interfering with iron uptake or by delivering antibacterial agents to mycobacteria in host cells through the iron uptake pathway, as well as certain compounds that are useful in the assay methods, and also as antibacterial agents.
Public/Granted literature
- US20090297647A1 Assays, method and compositions that exploit a mycobacterial iron acquistion pathway in cells Public/Granted day:2009-12-03
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