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US08389226B2 Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids 失效
诊断，分层和监测体液中阿尔茨海默病和其他神经系统疾病的方法和组成

  • Patent Title: Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids
  • Patent Title (中): 诊断，分层和监测体液中阿尔茨海默病和其他神经系统疾病的方法和组成
  • Application No.: US13031120
    Application Date: 2011-02-18
  • Publication No.: US08389226B2
    Publication Date: 2013-03-05
  • Inventor: Sandip Ray , Anton Wyss-Coray
  • Applicant: Sandip Ray , Anton Wyss-Coray
  • Main IPC: G01N33/567
  • IPC: G01N33/567 ;  G01N33/48 ;  G01N31/00 ;  A61B5/00
Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids
Abstract:
The inventors have discovered a collection of proteinaceous biomarkers (“AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating AD biomarker levels.
Abstract(Chinese):

发明人已经发现了可以在周边生物流体样品中测量的蛋白质生物标志物（AD生物标志物）的集合，以帮助诊断神经变性疾病，特别是阿尔茨海默氏病和轻度认知障碍（MCI）。 本发明还提供了通过测试预期药剂来调节AD生物标志物水平的活性来鉴定用于治疗阿尔茨海默氏病的候选药物的方法。

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