Invention Grant
US08388979B2 Polypeptide having affinity for envelope virus constituent and use thereof in transferring substance into cell
有权
对包膜病毒成分具有亲和性的多肽及其将物质转移至细胞中的用途
- Patent Title: Polypeptide having affinity for envelope virus constituent and use thereof in transferring substance into cell
- Patent Title (中): 对包膜病毒成分具有亲和性的多肽及其将物质转移至细胞中的用途
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Application No.: US13546359Application Date: 2012-07-11
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Publication No.: US08388979B2Publication Date: 2013-03-05
- Inventor: Kuni Fushikida , Yoshitaka Kondo
- Applicant: Kuni Fushikida , Yoshitaka Kondo
- Applicant Address: JP Osaka
- Assignee: Ishihara Sangyo Kaisha, Ltd.
- Current Assignee: Ishihara Sangyo Kaisha, Ltd.
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2006-21882 20060131; JP2006-230513 20060828
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/12 ; A61K39/385 ; C12Q1/70 ; G01N33/53 ; G01N33/567 ; C12P1/00

Abstract:
Delivery proteins are provided for transferring a protein, antibody or foreign substance into a cell without impairing the function or structure thereof. Further, methods of transferring a foreign substance into a cell at a high efficiency by using the delivery protein or an envelope virus or inactivated envelope virus in combination with said delivery protein are provided. The inventors discovered that a protein containing a polypeptide having an affinity for a constituent of the envelope virus contributes to the efficient enclosure of the foreign substance in the envelope. Moreover, the inventors discovered that use of the delivery protein enables foreign substances to be included in an envelope virus or inactivated envelope virus and therefore makes it possible to efficiently transfer the substances into cells without damaging the physiological function thereof.
Public/Granted literature
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