Invention Grant
US08388953B2 Method of increasing cathepsin B-induced cleavage of amyloid-β peptides
有权
增加组织蛋白酶B诱导的淀粉样蛋白的切割的方法 肽
- Patent Title: Method of increasing cathepsin B-induced cleavage of amyloid-β peptides
- Patent Title (中): 增加组织蛋白酶B诱导的淀粉样蛋白的切割的方法 肽
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Application No.: US12826403Application Date: 2010-06-29
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Publication No.: US08388953B2Publication Date: 2013-03-05
- Inventor: Li Gan , Lennart Mucke , Erik Roberson , Sarah Mueller-Steiner
- Applicant: Li Gan , Lennart Mucke , Erik Roberson , Sarah Mueller-Steiner
- Applicant Address: US CA San Francisco
- Assignee: The J. David Gladstone Institutes
- Current Assignee: The J. David Gladstone Institutes
- Current Assignee Address: US CA San Francisco
- Agency: Bozicevic, Field & Francis LLP.
- Agent Paula A. Borden
- Main IPC: A61K38/43
- IPC: A61K38/43
Abstract:
The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-β (Aβ) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tissue. The present invention further provides variant cathepsin B polypeptides that are resistant to inhibition by a cysteine protease inhibitor; as well as nucleic acids encoding the variants, and host cells comprising the nucleic acids.
Public/Granted literature
- US20110256120A1 Methods and Compositions for Reducing Amyloid Beta Levels Public/Granted day:2011-10-20
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