The present invention provides a liquid crystal cell manufacturing device and a method thereof. The liquid crystal cell manufacturing device includes a pre-alignment vacuum chamber, a vacuum lamination chamber and a sealant curing chamber. The pre-alignment vacuum chamber includes a comb-type transferring system for aligning a first substrate with a second substrate and sending them into the vacuum lamination chamber. The vacuum lamination chamber uses a lamination device to laminate the first substrate and the second substrate into a substrate assembly under a nearly vacuum status, and then uses a transferring device to send the substrate assembly to the sealant curing chamber. The sealant curing chamber uses at least one UV spot light source to move above the substrate assembly and irradiate a surface of the substrate assembly to cure at least one sealant in the substrate assembly, and thereby complete manufacture of liquid crystal cells of liquid crystal panels.