A medical liquid applicator system that includes an applicator grip assembly, a flexible reservoir and an applicator head. The applicator grip assembly is composed of a first section with a first distal end and a second section with a second distal end, a longitudinal axis, a front side, a back side, a predetermined grip length, a predetermined grip width, a fold axis separating the first section and the second section, the fold axis being perpendicular to the longitudinal axis, and a fold-activated dispensing slit located on the fold axis. The flexible reservoir is joined to a back side of the applicator grip assembly and is in liquid communication with the fold-activated dispensing slit. The applicator head is joined to the front side of the applicator grip assembly at the fold axis and is in liquid communication with the dispensing slit. The applicator grip assembly is folded at the fold axis to bring the back side of at least a portion of the first distal end of the first section and the back side of at least a portion of the second distal end of the second section together to define a grip handle having the predetermined grip length and the predetermined grip width. Folding the applicator grip assembly ruptures the fold-activated dispensing slit thereby defining a dispensing opening and also applies pressure to the flexible reservoir element in liquid communication with the dispensing slit to urge flowable medical liquid through the dispensing opening and into the applicator head.