A wake-and-go mechanism is provided for a data processing system. The wake-and-go mechanism recognizes a programming idiom, specialized instruction, operating system call, or application programming interface call that indicates that a thread is waiting for an event. The wake-and-go mechanism updates a wake-and-go array with a target address, expected data value, and comparison type associated with the event. The thread then goes to sleep until the event occurs. The wake-and-go array may be a content addressable memory (CAM). When a transaction appears on the symmetric multiprocessing (SMP) fabric that modifies the value at a target address in the CAM, logic associated with the CAM performs a comparison based on the data value being written, expected data value, and comparison type.