Invention Grant
US08383622B2 Nitrogen-containing heterocyclic derivative having 11β-hydroxysteroid dehydrogenase type I inhibitory activity
有权
具有11β-羟基类固醇脱氢酶I型抑制活性的含氮杂环衍生物
- Patent Title: Nitrogen-containing heterocyclic derivative having 11β-hydroxysteroid dehydrogenase type I inhibitory activity
- Patent Title (中): 具有11β-羟基类固醇脱氢酶I型抑制活性的含氮杂环衍生物
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Application No.: US12599133Application Date: 2008-05-07
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Publication No.: US08383622B2Publication Date: 2013-02-26
- Inventor: Koji Masuda , Tomoyuki Ogawa , Takuji Nakatani
- Applicant: Koji Masuda , Tomoyuki Ogawa , Takuji Nakatani
- Applicant Address: JP Osaka
- Assignee: Shionogi & Co., Ltd.
- Current Assignee: Shionogi & Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: JP2007-132259 20070518; JP2007-327114 20071219
- International Application: PCT/JP2008/058461 WO 20080507
- International Announcement: WO2008/142986 WO 20081127
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/415 ; A61K31/4245 ; A61K31/421 ; C07D231/10 ; C07D271/10 ; C07D263/04 ; C07D413/12 ; A61P3/10

Abstract:
Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor.A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is a group represented by the formula: Ring B is optionally substituted heteroaryl, provided that optionally substituted isoxazole is excluded, or optionally substituted heterocycle, R1 is hydrogen or optionally substituted alkyl, R2 is —OR5, —SR5, halogen, halogenated alkyl or the like, R3 is optionally substituted alkyl or the like, R4 is optionally substituted alkyl or the like, R5 is optionally substituted alkyl or the like, R6 is hydrogen or the like, R7 and R8 are each independently hydrogen or the like, R10 and R11 are each independently hydrogen or the like, R12 is optionally substituted alkyl or the like, m and p are each independently integer of 1 to 3.
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